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There are 4 four-letter words containing A, C, D and E

ACEDaced v. Simple past tense and past participle of ace.
ACE v. to serve an unreturnable shot e.g. in tennis.
CADEcade adj. (Of an animal) abandoned by its mother and reared by hand.
cade n. An animal brought up or nourished by hand.
cade v. To make a pet of; to coddle, pamper, or spoil.
DACEdace n. The shoal-forming fish Leuciscus leuciscus common to swift rivers in England and Wales and in Europe.
dace n. (US) Any of various related small fish of the family Cyprinidae that live in freshwater and are native…
DACE n. a small river fish of the carp family and chub genus.
ECADecad n. (Ecology) An organism whose form has been affected by its environment.
ecad n. A non-inherited somatic modification caused by an organism’s environment.
ECAD n. a plant which has supposedly adapted to its environment.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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