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There are 18 twelve-letter words containing A, O, P, U and X

AUTOEXPOSUREautoexposure n. (Photography) automatic selection of exposure settings.
AUTOEXPOSURE n. a system for automatically adjusting the aperture and/or shutter speed of a camera according to the lighting conditions.
AUXOTROPHIESauxotrophies n. Plural of auxotrophy.
AUXOTROPHY n. the state of being auxotrophic, requiring a specific growth substance beyond the minimum required for normal metabolism.
EXCULPATIONSexculpations n. Plural of exculpation.
EXCULPATION n. the act of exculpating.
EXOPHTHALMUSexophthalmus n. Alternative form of exophthalmos.
Exophthalmus prop.n. A taxonomic genus within the family Curculionidae – certain broad-nosed weevils.
EXOPHTHALMUS n. abnormal protrusion of the eyeball, also EXOPHTHALMOS.
EXPOSTULATEDexpostulated v. Simple past tense and past participle of expostulate.
EXPOSTULATE v. to remonstrate; to discuss or reason with.
EXPOSTULATESexpostulates v. Third-person singular simple present indicative form of expostulate.
EXPOSTULATE v. to remonstrate; to discuss or reason with.
EXPOSTULATORexpostulator n. One who expostulates.
EXPOSTULATOR n. one who expostulates.
EXPUGNATIONSexpugnations n. Plural of expugnation.
EXPUGNATION n. the act of expugning.
EXPURGATIONSexpurgations n. Plural of expurgation.
EXPURGATION n. the act of expurgating.
HAPAXANTHOUShapaxanthous adj. Being or relating to a hapaxanth.
HAPAXANTHOUS adj. monocarpous, also HAPAXANTHIC.
OXYCEPHALOUSOXYCEPHALOUS adj. having a conical skull, also OXYCEPHALIC.
PARADOXURINEparadoxurine adj. Of, or pertaining to, the genus Paradoxurus.
PARADOXURINE n. any of a number of palm civet species.
PNEUMOTHORAXpneumothorax n. (Medicine) Presence of air inside the pleural cavity, usually caused by injury either to the lung or the chest wall.
PNEUMOTHORAX n. accumulation of air or gas in the pleural cavity.
PORTMANTEAUXportmanteaux n. Plural of portmanteau.
PORTMANTEAU n. (French) a case opening in two parts, used for carrying clothes while traveling, also PORTMANTLE, PORTMANTUA.
PSYCHOSEXUALpsychosexual adj. Of or relating to the psychological aspect or aspects of sexuality.
PSYCHOSEXUAL adj. of or relating to the mental, emotional, and behavioral aspects of sexual development.
PYRRHULOXIASpyrrhuloxias n. Plural of pyrrhuloxia.
PYRRHULOXIA n. a grey-and-pink crested bunting of Central and SW North America, with a short parrot-like bill.
SULPHADOXINEsulphadoxine n. Alternative spelling of sulfadoxine.
SULPHADOXINE n. an antibiotic drug of the sulphonamide group, commonly used in combination with pyrimethamine to treat malaria, also SULFADOXINE.
XIPHOPAGUSESXIPHOPAGUS n. a set of Siamese twins joined in the region of the xiphoid cartilage.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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