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There are 5 eight-letter words containing 2A, C and 2U

ACAULOUSacaulous adj. (Botany) acaulescent.
ACAULOUS adj. having a very short stem, also ACAULINE, ACAULOSE.
AURICULAauricula n. (Anatomy) The external part of the ear.
auricula n. (Anatomy) A small conical pouch projecting from either atrium of the heart.
auricula n. (Palynology) A pronounced thickening at the corner of a trilete spore, beyond the end of the laesura.
CLAUSULAclausula n. (Music) The conclusion of a passage; cadence.
clausula n. The close or end of a historical period; clause.
CLAUSULA n. (Latin) a short clause ending a period in Latin prose.
CUNABULAcunabula n. The earliest abode; original dwelling place; originals.
cunabula n. The extant copies of the first or earliest printed books, or of such as were printed in the 15th century.
CUNABULA n. (Latin) the extant copies of the first printed books.
GUAIACUMguaiacum n. Any of a number of species of tree of the genus Guaiacum, native to the West Indies and parts of the Americas.
guaiacum n. The wood or resin of this tree.
GUAIACUM n. a medicinal resin, also GUAIAC, GUAIOCUM.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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