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There are 8 twelve-letter words containing 2A, L, 2S and X

ALEXANDERSESALEXANDERS n. an umbelliferous plant, the stems of which were formerly eaten as celery is now.
ASEXUALITIESasexualities n. Plural of asexuality.
ASEXUALITY n. the state of being asexual.
CARBOXYLASEScarboxylases n. Plural of carboxylase.
CARBOXYLASE n. an enzyme that catalyzes decarboxylation or carboxylation.
LAXATIVENESSlaxativeness n. The quality of being laxative.
LAXATIVENESS n. the state of being laxative.
PANSEXUALISMpansexualism n. (Psychology, historical) The psychological theory that all human activity (mental and physical) is based on sexuality.
pansexualism n. (Rare, chiefly derogatory) Pansexuality.
PANSEXUALISM n. the theory that all thought derives from the sexual instinct.
PANSEXUALISTpansexualist adj. (Psychology) Pertaining to or promoting the psychological theory of pansexualism.
pansexualist n. (Psychology) A proponent of the psychological theory of pansexualism.
pansexualist n. (Rare, sometimes derogatory) A person who is attracted, or who is able to experience attraction, to…
SEXAGESIMALSsexagesimals n. Plural of sexagesimal.
SEXAGESIMAL n. a sexagesimal fraction.
TRANSSEXUALStranssexuals n. Plural of transsexual.
TRANSSEXUAL n. a person anatomically of one sex but having a strong desire to adopt the physical characteristics and role of a member of the opposite sex, also TRANSEXUAL.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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