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There are 6 eight-letter words containing 2A, C, D, 2E and S

ACADEMESacademes n. Plural of academe.
ACADEME n. the academic life or world, also ACADEMIA.
CASEATEDcaseated v. Simple past tense and past participle of caseate.
CASEATE v. to become cheesy.
ESCALADEescalade n. An act of scaling walls or fortifications.
escalade v. (Military, dated) To scale the walls of a fortification.
ESCALADE v. (French) to scale the walls of a fortress by ladders, also ESCALADO, SCALADE, SCALADO.
ESCAPADEescapade n. A daring or adventurous act; an undertaking which goes against convention.
ESCAPADE n. a reckless adventure.
ESTACADEestacade n. (Military) A dike of piles in the sea, a river, etc., to hinder the approach of an enemy.
ESTACADE n. (French) a dike of stakes in a river against an enemy.
HEADCASEheadcase n. (Informal, derogatory) A mentally unbalanced, unpredictable person, especially one who displays aggressive behavior.
headcase n. (Genetics) A genetic sequence that inhibits terminal branching of the trachea and regulates dendrite pruning.
head-case n. Alternative spelling of headcase.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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