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There are 18 words containing 2A, D, 2E, F and M

DEFAMILIARIZEdefamiliarize v. (Transitive) To make unfamiliar; to divest of familiarity.
DEFAMILIARIZEDdefamiliarized v. Simple past tense and past participle of defamiliarize.
DEFAMILIARIZESdefamiliarizes v. Third-person singular simple present indicative form of defamiliarize.
DEFRAGMENTATIONdefragmentation n. (Computing) The action of defragmenting, particularly with respect to a computer disk or drive.
DEMOCRATIFIABLEDEMOCRATIFIABLE adj. able to be made democratic.
FACEPALMEDfacepalmed v. Simple past tense and past participle of facepalm.
FACEPALM v. to bring the palm of one's hand to one's face as an expression of dismay.
FRAGMENTATEDfragmentated v. Simple past tense and past participle of fragmentate.
FRAGMENTATE v. to reduce to fragments.
FUNDAMENTALNESSfundamentalness n. The state or condition of being fundamental; essential importance.
FUNDAMENTAL n. basic.
HAMFATTEREDHAMFATTER v. to perform as a third-rate minstrel.
HEADFRAMEheadframe n. (Mining) the structure supporting machinery above the entrance to an underground mineshaft.
HEADFRAME n. the structure over a mine shaft supporting the machinery.
HEADFRAMESheadframes n. Plural of headframe.
HEADFRAME n. the structure over a mine shaft supporting the machinery.
PREMANUFACTUREDpremanufactured v. Simple past tense and past participle of premanufacture.
PREMANUFACTURE v. to manufacture in advance.
REMANUFACTUREDremanufactured v. Simple past tense and past participle of remanufacture.
remanufactured adj. Having the property of having undergone remanufacture.
REMANUFACTURE v. to manufacture into a new product.
SHAMEFACEDshamefaced adj. Bashful, showing modesty or embarrassment.
shamefaced adj. Ashamed, displaying shame, especially by blushing in the face.
SHAMEFACED adj. showing modesty, also SHAMEFAST.
SHAMEFACEDLYshamefacedly adv. In a shamefaced manner.
SHAMEFACED adv. showing modesty, also SHAMEFAST.
SHAMEFACEDNESSshamefacedness n. The characteristic of being shamefaced.
SHAMEFACEDNESS n. the state of being shamefaced.
SULFACETAMIDEsulfacetamide n. (Pharmacology) A sulfonamide antibiotic.
sulfacetamide n. (Organic chemistry) The amide of sulfacetic acid.
SULFACETAMIDE n. a sulphonamide used in eye drops against conjunctivitis, etc., also SULPHACETAMIDE.
SULFACETAMIDESSULFACETAMIDE n. a sulphonamide used in eye drops against conjunctivitis, etc., also SULPHACETAMIDE.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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