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There are 18 words containing 2A, D, 2E, F and M

HEADFRAMEheadframe n. (Mining) the structure supporting machinery above the entrance to an underground mineshaft.
HEADFRAME n. the structure over a mine shaft supporting the machinery.
FACEPALMEDfacepalmed v. Simple past tense and past participle of facepalm.
FACEPALM v. to bring the palm of one's hand to one's face as an expression of dismay.
HEADFRAMESheadframes n. Plural of headframe.
HEADFRAME n. the structure over a mine shaft supporting the machinery.
SHAMEFACEDshamefaced adj. Bashful, showing modesty or embarrassment.
shamefaced adj. Ashamed, displaying shame, especially by blushing in the face.
SHAMEFACED adj. showing modesty, also SHAMEFAST.
HAMFATTEREDHAMFATTER v. to perform as a third-rate minstrel.
FRAGMENTATEDfragmentated v. Simple past tense and past participle of fragmentate.
FRAGMENTATE v. to reduce to fragments.
SHAMEFACEDLYshamefacedly adv. In a shamefaced manner.
SHAMEFACED adv. showing modesty, also SHAMEFAST.
DEFAMILIARIZEdefamiliarize v. (Transitive) To make unfamiliar; to divest of familiarity.
SULFACETAMIDEsulfacetamide n. (Pharmacology) A sulfonamide antibiotic.
sulfacetamide n. (Organic chemistry) The amide of sulfacetic acid.
SULFACETAMIDE n. a sulphonamide used in eye drops against conjunctivitis, etc., also SULPHACETAMIDE.
DEFAMILIARIZEDdefamiliarized v. Simple past tense and past participle of defamiliarize.
DEFAMILIARIZESdefamiliarizes v. Third-person singular simple present indicative form of defamiliarize.
REMANUFACTUREDremanufactured v. Simple past tense and past participle of remanufacture.
remanufactured adj. Having the property of having undergone remanufacture.
REMANUFACTURE v. to manufacture into a new product.
SHAMEFACEDNESSshamefacedness n. The characteristic of being shamefaced.
SHAMEFACEDNESS n. the state of being shamefaced.
SULFACETAMIDESSULFACETAMIDE n. a sulphonamide used in eye drops against conjunctivitis, etc., also SULPHACETAMIDE.
DEFRAGMENTATIONdefragmentation n. (Computing) The action of defragmenting, particularly with respect to a computer disk or drive.
DEMOCRATIFIABLEDEMOCRATIFIABLE adj. able to be made democratic.
FUNDAMENTALNESSfundamentalness n. The state or condition of being fundamental; essential importance.
FUNDAMENTAL n. basic.
PREMANUFACTUREDpremanufactured v. Simple past tense and past participle of premanufacture.
PREMANUFACTURE v. to manufacture in advance.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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