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There are 18 words containing 2A, 2E, 2F and N

CAFFEINATEcaffeinate v. (Transitive) To add caffeine to.
caffeinate v. (Intransitive, slang) To drink caffeinated beverages in order to increase one’s energy or wakefulness…
caffeinate v. (Transitive, slang) To inject tension into (A situation, etc.) for one’s own amusement; to stir things up.
CAFFEINATEDcaffeinated adj. Containing caffeine naturally (e.g., coffee, tea, and cacao) or as an additive (e.g., soft drinks, sports…
caffeinated adj. (Informal, of a person) Overly peppy or energetic; stimulated by caffeine.
caffeinated v. Simple past tense and past participle of caffeinate.
CAFFEINATEScaffeinates v. Third-person singular simple present indicative form of caffeinate.
AFFECTIONATEaffectionate adj. (Of a person) Having affection or warm regard; loving; fond.
affectionate adj. (Of an action, etc.) Characterised by or proceeding from affection; indicating love; tender.
affectionate adj. (Obsolete) Eager; passionate; strongly inclined toward something.
DECAFFEINATEdecaffeinate v. (Transitive) To remove the caffeine from something (especially from coffee).
DECAFFEINATE v. to remove caffeine from.
INEFFACEABLEineffaceable adj. Incapable of being effaced.
INEFFACEABLE adj. not effaceable.
INEFFACEABLYineffaceably adv. In an ineffaceable manner; in a manner that cannot be removed or erased.
INEFFACEABLE adv. not effaceable.
DECAFFEINATEDdecaffeinated adj. From which caffeine has been removed (e.g. decaffeinated coffee).
DECAFFEINATE v. to remove caffeine from.
DECAFFEINATESdecaffeinates v. Third-person singular simple present indicative form of decaffeinate.
DECAFFEINATE v. to remove caffeine from.
DIEFFENBACHIAdieffenbachia n. Any of several plants, of the genus Dieffenbachia, cultivated as houseplants.
Dieffenbachia prop.n. A taxonomic genus within the family Araceae – the mother-in-law’s tongue, dumb cane and similar plants.
DIEFFENBACHIA n. any plant of the tropical American araceous genus Dieffenbachia, including the dumbcane.
AFFECTIONATELYaffectionately adv. In an affectionate manner.
AFFECTIONATE adv. having affection or warm regard.
DECAFFEINATINGdecaffeinating v. Present participle of decaffeinate.
DECAFFEINATE v. to remove caffeine from.
DIEFFENBACHIASdieffenbachias n. Plural of dieffenbachia.
DIEFFENBACHIA n. any plant of the tropical American araceous genus Dieffenbachia, including the dumbcane.
UNAFFECTIONATEunaffectionate adj. Not affectionate; dispassionate.
UNAFFECTIONATE adj. not affectionate.
AFFRANCHISEMENTaffranchisement n. The act of freeing; enfranchisement.
AFFRANCHISEMENT n. the act of affranchising.
DISAFFECTIONATEdisaffectionate adj. Not disposed to affection; unfriendly.
DISAFFECTIONATE adj. showing disaffection.
INEFFACEABILITYineffaceability n. Quality of being ineffaceable.
INEFFACEABILITY n. the state of being ineffaceable.
REAFFORESTATIONreafforestation n. Reforestation.
REAFFORESTATION n. the act of reafforesting.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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