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There are 12 words containing A, 2C, 2F, I and O

EFFICACIOUSefficacious adj. (Formal) Effective; possessing efficacy.
EFFICACIOUS adj. having the power to produce a desired effect.
CYCLOPARAFFINcycloparaffin n. (Chemistry) A cycloalkane.
CYCLOPARAFFIN n. a saturated hydrocarbon containing a ring of carbon atoms joined by single bonds, aka cycloalkane.
EFFICACIOUSLYefficaciously adv. In an efficacious manner.
EFFICACIOUS adv. having the power to produce a desired effect.
INEFFICACIOUSinefficacious adj. Incapable of having the intended consequence.
inefficacious adj. Not effective.
INEFFICACIOUS adj. lacking the power to produce a desired effect.
CYCLOPARAFFINScycloparaffins n. Plural of cycloparaffin.
CYCLOPARAFFIN n. a saturated hydrocarbon containing a ring of carbon atoms joined by single bonds, aka cycloalkane.
FRUCTIFICATIONfructification n. (Botany) The act of forming or producing fruit; the act of fructifying, or rendering productive of fruit; fecundation.
fructification n. (Botany) The collective organs by which a plant produces its fruit, or seeds, or reproductive spores.
FRUCTIFICATION n. the reproductive organs or fruit of a plant.
DIFFRACTOMETRICdiffractometric adj. Relating to diffractometry; measured using a diffractometer.
DIFFRACTOMETRIC adj. relating to measurement by diffractometer, an instrument for determining structure of crystal through light diffraction.
EFFICACIOUSNESSefficaciousness n. Quality of being efficacious.
EFFICACIOUS n. having the power to produce a desired effect.
FRENCHIFICATIONFrenchification n. The act or process of making French or more French-like, especially in informal contexts.
Frenchification n. (Slang) Something that has undergone frenchification, something that has frenchified and made more French-like.
Frenchification n. Synonym of Gallicization, translation into French or a French translation.
FRUCTIFICATIONSfructifications n. Plural of fructification.
FRUCTIFICATION n. the reproductive organs or fruit of a plant.
INEFFICACIOUSLYinefficaciously adv. Without efficacy or effect.
INEFFICACIOUS adv. lacking the power to produce a desired effect.
SCHIZOAFFECTIVEschizoaffective adj. (Psychiatry) Combining the symptoms of schizophrenia with those of bipolar disorder.
schizoaffective n. A person who has a schizoaffective disorder.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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