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There are 12 words containing A, 2D, 2E, F and M

DEFAMEDdefamed v. Simple past tense and past participle of defame.
DEFAME v. to destroy the reputation of.
DEFOAMEDdefoamed v. Simple past tense and past participle of defoam.
DEFOAM v. to remove foam from.
MADEFIEDmadefied v. Simple past tense and past participle of madefy.
MADEFY v. (archaic) to moisten.
FOREDAMNEDforedamned adj. Damned beforehand.
foredamned v. Simple past tense and past participle of foredamn.
fore-damned adj. Alternative form of foredamned.
DEFRAUDMENTdefraudment n. (Obsolete) Privation by fraud; defrauding.
DEFRAUDMENT n. the act of defrauding.
DEFORMALISEDDEFORMALISE v. to make less formal, also DEFORMALIZE.
DEFORMALIZEDdeformalized v. Simple past tense and past participle of deformalize.
DEFORMALIZE v. to make less formal, also DEFORMALISE.
DEFRAGMENTEDdefragmented v. Simple past tense and past participle of defragment.
DEFRAGMENT v. to run a program which reduces or eliminates the fragmentation of (a file or disk) by bringing together parts of files stored in separate locations to a single location on the disk.
DEFRAUDMENTSdefraudments n. Plural of defraudment.
DEFRAUDMENT n. the act of defrauding.
FORMALDEHYDEformaldehyde n. (Organic chemistry) The simplest aldehyde, HCHO, a colourless gas that has many industrial applications;…
FORMALDEHYDE n. a formic aldehyde, formalin.
FORMALDEHYDESformaldehydes n. Plural of formaldehyde.
FORMALDEHYDE n. a formic aldehyde, formalin.
DEFAMILIARIZEDdefamiliarized v. Simple past tense and past participle of defamiliarize.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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