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There are 20 twelve-letter words containing 2A, D, 2E, I and 2S

ADAPTIVENESSadaptiveness n. The state or quality of being adaptive; capacity to adapt.
ADAPTIVENESS n. the quality of being adaptive.
ADVERSATIVESadversatives n. Plural of adversative.
ADVERSATIVE n. a word or phrase expressing opposition.
ASCENDANCIESascendancies n. Plural of ascendancy.
ASCENDANCY n. the state of being ascendant, also ASCENDANCE, ASCENDENCE, ASCENDENCY.
ASTEROIDEANSasteroideans n. Plural of asteroidean.
ASTEROIDEAN n. an echinoderm of the class Asteroidea, comprising the starfishes.
CALENDARISEScalendarises v. Third-person singular simple present indicative form of calendarise.
CALENDARISE v. in accounting, to divide (something, e.g. a budget) into equal units of time within a year (usually months), also CALENDARIZE.
DECASUALISEDDECASUALISE v. (US) to replace the casual workers in (a business) with permanent employees, also DECASUALIZE.
DECASUALISESDECASUALISE v. (US) to replace the casual workers in (a business) with permanent employees, also DECASUALIZE.
DECASUALIZESdecasualizes v. Third-person singular simple present indicative form of decasualize.
DECASUALIZE v. (US) to replace the casual workers in (a business) with permanent employees, also DECASUALISE.
DEDRAMATISESDEDRAMATISE v. to play down the importance of, lessen or keep low the tension or friction caused by, also DEDRAMATIZE.
DERACIALISESderacialises v. Third-person singular simple present indicative form of deracialise.
DERACIALISE v. to divest of racial character, also DERACIALIZE.
DESACRALISEDDESACRALISE v. to deprive or remove sacred qualities, also DESACRALIZE.
DESACRALISESDESACRALISE v. to deprive or remove sacred qualities, also DESACRALIZE.
DESACRALIZESdesacralizes v. Third-person singular simple present indicative form of desacralize.
DESACRALIZE v. to divest of supernatural qualities, also DESACRALISE.
DISCALCEATESdiscalceates v. Third-person singular simple present indicative form of discalceate.
DISCALCEATE n. one who goes unshod, a discalced friar.
DISPLEASANCEdispleasance n. (Obsolete) Displeasure, dissatisfaction.
DISPLEASANCE n. (Spenser) displeasure.
DYSAESTHESIAdysaesthesia n. Alternative spelling of dysesthesia.
dysæsthesia n. Obsolete spelling of dysesthesia.
DYSAESTHESIA n. loss of sensation.
METASTASISEDmetastasised v. Simple past tense and past participle of metastasise.
METASTASISE v. to spread or grow by or as if by metastasis, also METASTASIZE.
METASTASIZEDmetastasized v. Simple past tense and past participle of metastasize.
METASTASIZE v. to spread or grow by or as if by metastasis, also METASTASISE.
PAEDERASTIESPAEDERASTY n. anal intercourse between a man and a boy, also PEDERASTY.
RADIESTHESIAradiesthesia n. The supposed paranormal ability to detect a radiation-like aura within the human body.
RADIESTHESIA n. sensitivity to radiation from any source.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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