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There are 18 twelve-letter words containing A, C, E, F, N, S and 2T

AFFECTATIONSaffectations n. Plural of affectation.
AFFECTATION n. the act of taking on an attitude not natural to oneself or not genuinely felt.
COUNTERSHAFTcountershaft n. Synonym of jackshaft (“mechanical component for rotational force”).
countershaft v. Synonym of jackshaft.
COUNTERSHAFT n. an intermediate shaft driven by the main shaft.
DISINFECTANTdisinfectant adj. Serving to kill germs or viruses.
disinfectant n. A substance that kills germs and/or viruses.
DISINFECTANT n. an agent that frees from infection.
FANTASTICATEfantasticate v. (Transitive) To make fantastical.
fantasticate v. (Intransitive) To behave fantastically.
FANTASTICATE v. to fantasize over something.
FANTASTICOESFANTASTICO n. (Shakespeare) a dandy.
FIANCHETTOESfianchettoes v. Third-person singular simple present indicative form of fianchetto.
FIANCHETTO v. to develop the bishop.
FRACTIONATESfractionates v. Third-person singular simple present indicative form of fractionate.
FRACTIONATE v. to separate a mixture into different portions esp. by a fractional process.
FRACTIONLETSFRACTIONLET n. a small fraction.
FUNCTIONATESfunctionates v. Third-person singular simple present indicative form of functionate.
FUNCTIONATE v. to perform a function.
METAFICTIONSmetafictions n. Plural of metafiction.
METAFICTION n. fiction which refers to or takes as its subject fictional writing and its conventions.
PONTIFICATESpontificates n. Plural of pontificate.
PONTIFICATE v. to speak in a pompous and dogmatic manner.
STUPEFACIENTstupefacient adj. (Medicine) Inducing stupor or drowsiness (with a drug such as a narcotic or an anaesthetic).
stupefacient n. (Medicine) Any drug that induces stupor or drowsiness.
STUPEFACIENT n. a narcotic, a stupefying drug.
STUPEFACTIONstupefaction n. The state of extreme shock or astonishment.
stupefaction n. A state of insensibility; stupor.
STUPEFACTION n. the act of stupefying.
TABEFACTIONStabefactions n. Plural of tabefaction.
TABEFACTION n. wasting away, emaciation.
TEPEFACTIONSTEPEFACTION n. making or becoming tepid.
TRANSFECTINGtransfecting v. Present participle of transfect.
TRANSFECT v. to cause transfection in, the infection of a cell with pure viral nucleic acid.
TRANSFECTIONtransfection n. (Molecular biology) The introduction of foreign genetic material (such as DNA or RNA) into a eukaryotic cell.
TRANSFECTION n. the infection of a cell with pure viral nucleic acid.
TUMEFACTIONStumefactions n. Plural of tumefaction.
TUMEFACTION n. swelling.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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See this list for:

  • English Wiktionary: 51 words
  • Scrabble in French: 42 words
  • Scrabble in Spanish: 27 words
  • Scrabble in Italian: 44 words
  • Scrabble in German: no word
  • Scrabble in Romanian: 16 words


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