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There are 14 twelve-letter words containing A, D, E, 2I, M and 2R

IMPROPRIATEDimpropriated v. Simple past tense and past participle of impropriate.
IMPROPRIATE v. to transfer ecclesiastical revenue to a layman.
INTERMARRIEDintermarried v. Simple past tense and past participle of intermarry.
INTERMARRY v. to marry each other.
INTERMEDIARYintermediary adj. Intermediate.
intermediary n. An agent acting as a mediator between sides to facilitate agreement or cooperation.
intermediary n. A person or organisation in an intermediate position (In a transaction, agreement, supply chain etc.).
IRREMEDIABLEirremediable adj. Unable to be remedied, cured, corrected or repaired; irreparable, incurable.
IRREMEDIABLE adj. not remediable.
IRREMEDIABLYirremediably adv. In a manner, or to a degree, that precludes remedy, cure, or correction; in an irremediable way.
IRREMEDIABLE adv. not remediable.
MADREPORITICmadreporitic adj. Relating to or composed of madreporite.
MADREPORITIC adj. of or like madreporite, in echinoderms, a perforated plate serving as opening to the stone canal.
MISREGARDINGmisregarding v. Present participle of misregard.
MISREGARD v. (Spenser) to have no regard for.
MURDERABILIAmurderabilia n. Items associated with a murderer, regarded as collectibles.
MURDERABILIA n. objects that are regarded as valuable because of their connection with murders or other notorious crimes.
PERICARDIUMSpericardiums n. Plural of pericardium.
PERICARDIUM n. a membranous sac containing the heart.
RADIOMETRIESradiometries n. Plural of radiometry.
RADIOMETRY n. the measurement of radiant energy.
READMINISTERreadminister v. (Transitive) to administer again.
RECRIMINATEDrecriminated v. Simple past tense and past participle of recriminate.
RECRIMINATE v. to charge one's accuser.
REMAINDERINGremaindering v. Present participle of remainder.
REMAINDER v. to sell as a remainder.
REPRIMANDINGreprimanding v. Present participle of reprimand.
REPRIMAND v. to scold, censure.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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