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There are 15 four-letter words containing C and 2O

COCOcoco n. Coconut palm.
coco n. Coconut, the fruit of the coconut palm.
Coco prop.n. A surname from Sicilian.
COHOcoho n. An anadromus and semelparous salmon, Oncorhynchus kisutch, found in the coastal regions of the northern…
COHO n. a Pacific salmon, also COHOE.
COOFcoof n. (Scotland) An idiot, or fool.
coof n. (Internet slang) The coronavirus, particularly SARS-CoV-2.
COOF n. (Scots) a dolt, also CUIF.
COOKcook n. (Cooking) A person who prepares food.
cook n. (Cooking) The head cook of a manor house.
cook n. (Cooking) The degree or quality of cookedness of food.
COOLcool adj. Having a slightly low temperature; mildly or pleasantly cold.
cool adj. Allowing or suggesting heat relief.
cool adj. Of a color, in the range of violet to green.
COOMcoom n. Soot, smut.
coom n. Dust.
coom n. Grease.
COONcoon n. (Ethnic slur) A black person.
coon n. (Informal, chiefly Southern US) A raccoon.
coon n. (Informal, South Africa) A member of a colorfully dressed dance troupe in Cape Town during New Year celebrations.
COOPcoop n. A basket, pen or enclosure for birds or small animals.
coop n. A wickerwork basket (kipe) or other enclosure for catching fish.
coop n. (Figuratively, slang) A narrow place of confinement, a cage; a jail, a prison.
COOScoos v. Third-person singular simple present indicative form of coo.
coos n. Plural of coo.
COOs n. Plural of COO.
COOTcoot n. Any of various aquatic birds of the genus Fulica that are mainly black with a prominent frontal shield…
coot n. (Colloquial) A foolish or eccentric fellow.
coot n. (Slang, with the) A success; something excellent.
DOCOdoco n. (UK, Australia, informal) Abbreviation of documentary.
doco n. (Computing, informal) Abbreviation of documentation.
DOCO n. (Australian slang) a documentary.
JOCOJOCO n. (Scots) a joke.
LOCOloco adv. (Music) A direction in written or printed music to be returning to the proper pitch after having played…
loco adj. (Colloquial) Crazy.
loco adj. (Southwestern US) Intoxicated by eating locoweed.
POCOPOCO n. (Countable, object-oriented software) Acronym of plain old CLR object.
POCO n. (Uncountable, European politics) Acronym of political cooperation.
POCO adv. (Italian) as a musical direction, a little.
TOCOtoco n. Clipping of tocodynamometer.
toco n. (Obsolete, British slang) Corporal punishment; chastisement; beatings.
toco n. A toco toucan.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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