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There are 14 five-letter words containing C, E, M and S

ACMESacmes n. Plural of acme.
ACME n. (Greek) the highest point.
CAMEScames n. Plural of came.
CAME n. a lead rod for framing a pane in a leaded or stained glass window.
CHEMSchems n. Plural of chem.
CHEM n. (short for) a chemistry class or course.
CLEMSclems n. Plural of clem.
clems v. Third-person singular simple present indicative form of clem.
CLEM v. to starve.
COMEScomes v. Third-person singular simple present indicative form of come.
comes n. (Music) The answer to the theme, or dux, in a fugue.
Comes prop.n. A botanical plant name author abbreviation for botanist Orazio Comes (1848-1923).
CREMScrems n. Plural of crem.
CREM n. (colloquial) a crematorium.
CYMEScymes n. Plural of cyme.
CYME n. a type of flower cluster.
EMACSemacs n. (Computing) Any implementation or reimplementation of Emacs.
eMacs n. Plural of eMac.
Emacs prop.n. (Computing) A particular visual or WYSIWYG text editor (first written by Richard Stallman in 1975 but…
EMICSEMIC n. a type of linguistic analysis.
MACESmaces n. Plural of mace.
maces v. Third-person singular simple present indicative form of mace.
MACE v. to attack with a club-like weapon.
MECHSmechs n. Plural of mech.
mechs. n. Plural of mech.
MECH n. (short for) mechanic.
MECKSmecks n. Plural of meck.
MECK n. (Scots) an old halfpenny, also MAIK, MEG.
MERCSmercs n. Plural of merc.
Mercs n. Plural of Merc.
MERC n. (short for) a mercenary.
MESICmesic adj. (Biology, of a habitat) Moist.
mesic adj. (Biology, of an organism) Adapted to a moist habitat.
mesic adj. (Physics) Of or pertaining to mesons; mesonic.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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