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There are 20 twelve-letter words containing C, D, E, O and X

CARBOXYLATEDcarboxylated v. Simple past tense and past participle of carboxylate.
carboxylated adj. (Chemistry) Converted into a carboxylic acid, normally by the oxidation of an alcohol or aldehyde.
CARBOXYLATE v. to introduce carboxyl or carbon dioxide into (a compound) with formation of a carboxylic acid.
COADJUTRIXEScoadjutrixes n. Plural of coadjutrix.
COADJUTRIX n. a female coadjutor or assistant, also COADJUTRESS.
COMPLEXIFIEDcomplexified v. Simple past tense and past participle of complexify.
COMPLEXIFY v. to render complex.
COMPLEXIONEDcomplexioned adj. (In combination) Having a specified type of complexion.
COMPLEXIONED adj. having a particular complexion.
CYCLODEXTRINcyclodextrin n. (Biochemistry) Any of a class of cyclic oligosaccharides consisting of glucopyranose residues linked…
CYCLODEXTRIN n. any of several water-soluble carbohydrates with hydrophobic interiors, used to provide capsules for drugs.
DEOXYCORTONEdeoxycortone n. (Pharmacology) UK form of desoxycortone.
DEOXYCORTONE n. a corticosteroid hormone important in maintaining sodium and water balance in the body.
DETOXICATINGdetoxicating v. Present participle of detoxicate.
DETOXICATE v. to rid of a poison or the effects of it.
DETOXICATIONdetoxication n. (Biochemistry) Any metabolic process by which the toxicity of a material is reduced.
detoxication n. (Medicine) Any treatment of a patient suffering from poisoning that promotes physiological process to…
DETOXICATION n. the act of detoxicating.
DEXTROCARDIAdextrocardia n. (Medicine) A congenital abnormality in which the heart is transposed to the right side of the chest.
DEXTROCARDIA n. a condition in which the heart is on the right-hand side of the chest.
DISCONNEXIONdisconnexion n. Dated form of disconnection.
DISCONNEXION n. the act of disconnecting, also DISCONNECTION.
DOXYCYCLINESdoxycyclines n. Plural of doxycycline.
DOXYCYCLINE n. a broad-spectrum tetracycline antibiotic with potent antibacterial activity that is often taken by travelers to prevent diarrhea.
EXCORTICATEDexcorticated v. Simple past tense and past participle of excorticate.
EXCORTICATE v. to strip the bark off of.
EXPECTORATEDexpectorated v. Simple past tense and past participle of expectorate.
EXPECTORATE v. to eject from the throat or lungs by coughing or hawking and spitting.
HEXACHLORIDEhexachloride n. (Chemistry) Any chloride having six chlorine atoms.
HEXACHLORIDE n. a chloride containing six atoms of chlorine.
HEXADECANOIChexadecanoic adj. Of or pertaining to hexadecanoic acid or its derivatives.
HEXADECANOIC adj. as in hexadecanoic acid, a fatty acid, aka palmitic acid.
PHOTOEXCITEDphotoexcited v. Simple past tense and past participle of photoexcite.
photoexcited adj. (Chemistry, physics) (of an atom, molecule or ion) excited due to photoexcitation.
PHOTOEXCITED adj. relating to photoexcitation.
SEXDECILLIONsexdecillion num. (Rare, US, modern British & Australian, short scale) 1051.
sexdecillion num. (Rare, dated, British & Australian, long scale) 1096.
SEXDECILLION n. ten to the power of 51.
SEXTODECIMOSsextodecimos n. Plural of sextodecimo.
SEXTODECIMO n. a book size 5 5/8 in. x 4 3/8 in. (abbreviated as 16mo.), also SIXTEENMO.
XENODOCHIUMSxenodochiums n. Plural of xenodochium.
XENODOCHIUM n. a building for the reception of strangers, e.g. a guesthouse in a monastery.
XERODERMATICxerodermatic adj. Exhibiting or relating to xeroderma.
XERODERMATIC adj. relating to xeroderma, dryness of skin.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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