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There are 8 twelve-letter words containing C, D, E, Q and R

CHEQUERBOARDchequerboard n. Alternative spelling of checkerboard.
chequerboard v. Alternative spelling of checkerboard.
CHEQUERBOARD n. a board for playing chequers.
QUADRAPLEGICQUADRAPLEGIC n. one suffering from quadriplegia, paralysis of both arms and both legs, also QUADRIPLEGIC.
QUADRATRICESquadratrices n. Plural of quadratrix.
QUADRATRIX n. a curve by which a circle may be squared.
QUADRICEPSESquadricepses n. Plural of quadriceps.
QUADRICEPS n. the great extensor muscle of the knee, divided above into four parts which unite in a single tendon at the knee.
QUADRIPLEGICquadriplegic adj. Of, related to, or suffering from quadriplegia.
quadriplegic n. One who suffers from quadriplegia.
QUADRIPLEGIC adj. relating to quadriplegia, paralysis of both arms and both legs.
QUADRISECTEDquadrisected v. Simple past tense and past participle of quadrisect.
QUADRISECT v. to divide into four equal parts.
QUARTERDECKSquarterdecks n. Plural of quarterdeck.
quarter-decks n. Plural of quarter-deck.
quarter␣decks n. Plural of quarter deck.
REACQUAINTEDreacquainted v. Simple past tense and past participle of reacquaint.
REACQUAINT v. to acquaint again.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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