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There are 12 twelve-letter words containing C, D, 2F and S

AFFECTEDNESSaffectedness n. The state or quality of being affected.
AFFECTEDNESS n. the quality of being false or artificial.
AFFICIONADOSafficionados n. Plural of afficionado.
AFFICIONADO n. (Spanish) a devotee, admirer, an enthusiastic fan, also AFICIONADO.
AFFRANCHISEDaffranchised v. Simple past tense and past participle of affranchise.
AFFRANCHISE v. to free from slavery or similar obligation.
DIFFERENCIESDIFFERENCY v. to make or perceive a difference in, also DIFFERENCE.
DIFFICULTIESdifficulties n. Plural of difficulty.
difficulties n. (Colloquial) a series of frustrations.
DIFFICULTY n. the state of being difficult.
DIFFRACTIONSdiffractions n. Plural of diffraction.
DIFFRACTION n. a modification which light undergoes esp. in passing by the edges of opaque bodies or through narrow openings and in which the rays appear to be deflected.
DISAFFECTINGdisaffecting v. Present participle of disaffect.
DISAFFECT v. to take away the affection of; to make discontented or unfriendly.
DISAFFECTIONdisaffection n. Discontent; unrest.
disaffection n. Alienation; loss of loyalty.
DISAFFECTION n. the state of being disaffected.
OFFICIALDOMSofficialdoms n. Plural of officialdom.
OFFICIALDOM n. officials as a class.
SCAFFOLDAGESSCAFFOLDAGE n. the gallery of a theatre, also SCAFFOLAGE.
SCAFFOLDINGSscaffoldings n. Plural of scaffolding.
SCAFFOLDING n. a framework of platforms for painters.
SPIFFLICATEDspifflicated v. Simple past tense and past participle of spifflicate.
SPIFFLICATE v. to overcome or dispose of by violence, also SPIFLICATE.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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