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There are 2 five-letter words containing C, L, O, S and U

CLOUSclous n. Plural of clou.
CLOU n. (French) the main point of interest; a dominant idea.
LOCUSlocus n. A place or locality, especially a centre of activity or the scene of a crime.
locus n. (Mathematics) The set of all points whose coordinates satisfy a given equation or condition.
locus n. (Genetics) A fixed position on a chromosome that may be occupied by one or more genes.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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