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There are 7 eight-letter words containing C, 2F, O and T

CASTOFFScastoffs n. Plural of castoff.
cast-offs n. Plural of cast-off.
CASTOFF n. an item of clothing one no longer wishes to wear, and passes on to another, also OFFCAST.
CLIFFTOPclifftop n. The top of a cliff.
CLIFFTOP n. the top of a cliff.
COEFFECTcoeffect n. A joint effect.
COEFFECT n. an accompanying effect.
COFFRETScoffrets n. Plural of coffret.
COFFRET n. (French) a small strongbox.
EFFECTOReffector n. (Biology) Any muscle, organ etc. that can respond to a stimulus from a nerve.
effector n. (Biology) The part of a nerve that carries a stimulus to a muscle etc.
effector n. (Biology) Any small molecule that effects the function of an enzyme by binding to an allosteric site.
OFFCASTSoffcasts n. Plural of offcast.
OFFCAST n. an item of clothing one no longer wishes to wear, and passes on to another, also CASTOFF.
OFFTRACKofftrack adj. Alternative spelling of off-track.
off-track adj. Away from an intended route; wayward.
off-track adj. (Of gambling) conducted away from a racetrack.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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