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There are 10 fifteen-letter words containing 2D, 2E and F

DEDIFFERENTIATEdedifferentiate v. To lose or reverse differentiation.
DEDIFFERENTIATE v. to effect dedifferentiation, a change by which specialized tissue with several cell types reverts to a generalized and simpler form.
DIGNIFIEDNESSESDIGNIFIEDNESS n. the state of being dignified.
DISAFFECTEDNESSdisaffectedness n. The quality of being disaffected.
DISAFFECTEDNESS n. the state of being disaffected.
DISENFRANCHISEDdisenfranchised v. Simple past tense and past participle of disenfranchise.
disenfranchised adj. Not represented; especially, not having the right to vote.
DISENFRANCHISE v. to deprive of a franchise.
DISFELLOWSHIPEDdisfellowshiped v. Simple past tense and past participle of disfellowship; alternative spelling of disfellowshipped.
DISFELLOWSHIP v. to exclude from fellowship.
FATHEADEDNESSESFATHEADEDNESS n. FATHEADED, stupid.
FEATHERBEDDINGSFEATHERBEDDING n. protecting (an industry, workers, etc.) by such practices as overmanning in order to save jobs.
FURFURALDEHYDESFURFURALDEHYDE n. a liquid obtained by heating bran with dilute sulphuric acid, also FURAL, FURFURAL, FURFUROL, FURFUROLE, FUROL, FUROLE.
OFFHANDEDNESSESOFFHANDEDNESS n. the state of being offhanded.
UNFOUNDEDNESSESUNFOUNDEDNESS n. the state of being unfounded.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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