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There are 10 fifteen-letter words containing 2D, E, M and R

ANDROMEDOTOXINSandromedotoxins n. Plural of andromedotoxin.
ANDROMEDOTOXIN n. a poisonous substance extracted from plants of the heath family and used in medicine to lower high blood pressure.
CHORDAMESODERMSCHORDAMESODERM n. the layer of specialized cells in the middle of a developing embryo which forms the notochord and structures of the central nervous system.
DIMENHYDRINATESdimenhydrinates n. Plural of dimenhydrinate.
DIMENHYDRINATE n. a crystalline antihistamine used esp. to prevent nausea, as in motion sickness.
DIPHENHYDRAMINEdiphenhydramine n. (Pharmacology) An antihistamine and anticholinergic drug that blocks the effect of histamine at H1 receptor…
DIPHENHYDRAMINE n. a type of antihistamine.
DISCOMBOBERATEDdiscomboberated v. Simple past tense and past participle of discomboberate.
DISCOMBOBERATE v. to throw into a state of confusion, also DISCOMBOBULATE.
DISINTERMEDIATEdisintermediate v. (Business, banking, finance) To carry out disintermediation.
MALADMINISTEREDmaladministered v. Simple past tense and past participle of maladminister.
MALADMINISTER v. to administer wrongly.
MISCOMPREHENDEDmiscomprehended v. Simple past tense and past participle of miscomprehend.
MISCOMPREHEND v. to comprehend wrongly.
UNDEREMPHASISEDunderemphasised adj. Alternative spelling of underemphasized.
UNDEREMPHASISE v. to emphasise insufficiently, also UNDEREMPHASIZE.
UNDEREMPHASIZEDunderemphasized adj. Insufficiently emphasized.
UNDEREMPHASIZE v. to emphasise insufficiently, also UNDEREMPHASISE.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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