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There are 11 twelve-letter words containing 2D, E, F, M and R

DEFORMALISEDDEFORMALISE v. to make less formal, also DEFORMALIZE.
DEFORMALIZEDdeformalized v. Simple past tense and past participle of deformalize.
DEFORMALIZE v. to make less formal, also DEFORMALISE.
DEFORMEDNESSdeformedness n. (Obsolete, rare) The quality or state of being deformed.
DEFORMEDNESS n. the state of being deformed.
DEFRAGMENTEDdefragmented v. Simple past tense and past participle of defragment.
DEFRAGMENT v. to run a program which reduces or eliminates the fragmentation of (a file or disk) by bringing together parts of files stored in separate locations to a single location on the disk.
DEFRAUDMENTSdefraudments n. Plural of defraudment.
DEFRAUDMENT n. the act of defrauding.
DEHUMIDIFIERdehumidifier n. A device for removing the moisture content from air.
DEHUMIDIFIER n. an apparatus for reducing humidity.
DISCOMFORTEDdiscomforted v. Simple past tense and past participle of discomfort.
DISCOMFORT v. to make uncomfortable or uneasy.
DISCONFIRMEDdisconfirmed v. Simple past tense and past participle of disconfirm.
DISCONFIRM v. to deny the validity of.
DUMBFOUNDERSdumbfounders n. Plural of dumbfounder.
DUMBFOUNDER v. to strike dumb; to confuse with astonishment, also DUMBFOUND, DUMFOUND, DUMFOUNDER.
DUMFOUNDEREDdumfoundered v. Simple past tense and past participle of dumfounder.
DUMFOUNDER v. to strike dumb; to confuse with astonishment, also DUMBFOUND, DUMBFOUNDER, DUMFOUND.
FORMALDEHYDEformaldehyde n. (Organic chemistry) The simplest aldehyde, HCHO, a colourless gas that has many industrial applications;…
FORMALDEHYDE n. a formic aldehyde, formalin.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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