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There are 12 twelve-letter words containing 2D, F, N, R and S

DANDRUFFIESTDANDRUFFY adj. full of dandruff.
DEFIBRINISEDDEFIBRINISE v. to deprive of fibrin, also DEFIBRINIZE.
DEFORMEDNESSdeformedness n. (Obsolete, rare) The quality or state of being deformed.
DEFORMEDNESS n. the state of being deformed.
DEFRAUDMENTSdefraudments n. Plural of defraudment.
DEFRAUDMENT n. the act of defrauding.
DISCONFIRMEDdisconfirmed v. Simple past tense and past participle of disconfirm.
DISCONFIRM v. to deny the validity of.
DISFURNISHEDdisfurnished v. Simple past tense and past participle of disfurnish.
disfurnished adj. Deprived of furniture, accoutrements or belongings; stripped, destitute.
DISFURNISH v. to strip, render destitute.
DREADFULNESSdreadfulness n. The characteristic of being dreadful.
DREADFULNESS n. the state of being dreadful.
DUMBFOUNDERSdumbfounders n. Plural of dumbfounder.
DUMBFOUNDER v. to strike dumb; to confuse with astonishment, also DUMBFOUND, DUMFOUND, DUMFOUNDER.
FORBIDDANCESforbiddances n. Plural of forbiddance.
FORBIDDANCE n. (obsolete) the act of forbidding.
HUNDREDFOLDShundredfolds n. Plural of hundredfold.
HUNDREDFOLD n. a multiplication by one hundred.
SOUNDPROOFEDsoundproofed v. Simple past tense and past participle of soundproof.
SOUNDPROOF v. to insulate so as to obstruct the passage of sound.
UNDERSTAFFEDunderstaffed adj. Having an inadequate number of workers or assistants.
UNDERSTAFFED adj. inadequately staffed.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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