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There are 14 fifteen-letter words containing 2D, 2E, I and M

ADENOIDECTOMIESadenoidectomies n. Plural of adenoidectomy.
ADENOIDECTOMY n. the surgical removal of the adenoids, also ADENECTOMY.
DEMANDINGNESSESDEMANDINGNESS n. the state of being demanding.
DIMENHYDRINATESdimenhydrinates n. Plural of dimenhydrinate.
DIMENHYDRINATE n. a crystalline antihistamine used esp. to prevent nausea, as in motion sickness.
DIPHENHYDRAMINEdiphenhydramine n. (Pharmacology) An antihistamine and anticholinergic drug that blocks the effect of histamine at H1 receptor…
DIPHENHYDRAMINE n. a type of antihistamine.
DISCOMBOBERATEDdiscomboberated v. Simple past tense and past participle of discomboberate.
DISCOMBOBERATE v. to throw into a state of confusion, also DISCOMBOBULATE.
DISINTERMEDIATEdisintermediate v. (Business, banking, finance) To carry out disintermediation.
MADDENINGNESSESMADDENINGNESS n. the state of being maddening.
MALADMINISTEREDmaladministered v. Simple past tense and past participle of maladminister.
MALADMINISTER v. to administer wrongly.
MIDDELMANNETJIEmiddelmannetjie n. (South Africa) A ridge between ruts made by wheels in a dirt or gravel road.
MIDDELMANNETJIE n. (South African) a ridge between the ruts made by wheels in a dirt road.
MISCOMPREHENDEDmiscomprehended v. Simple past tense and past participle of miscomprehend.
MISCOMPREHEND v. to comprehend wrongly.
MISGUIDEDNESSESmisguidednesses n. Plural of misguidedness.
MISGUIDEDNESS n. the state of being misguided.
UNDEMANDINGNESSundemandingness n. The quality of being undemanding; lack of difficulty or challenge.
UNDEREMPHASISEDunderemphasised adj. Alternative spelling of underemphasized.
UNDEREMPHASISE v. to emphasise insufficiently, also UNDEREMPHASIZE.
UNDEREMPHASIZEDunderemphasized adj. Insufficiently emphasized.
UNDEREMPHASIZE v. to emphasise insufficiently, also UNDEREMPHASISE.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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