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There are 7 eight-letter words containing 2D, E, M, N and R

DAMNEDERdamneder adj. Comparative form of damned: more damned.
DAMNED adj. damnable.
DEMANDERdemander n. One who demands.
DEMANDER n. one who demands.
ENDODERMendoderm n. One of the three tissue layers in the embryo of a metazoan animal. Through development, it will produce…
ENDODERM n. the innermost layer of embryo, also ENTODERM.
REDEMANDredemand v. (Now rare) To demand the return of (someone or something).
redemand v. (Transitive) to demand again.
redemand n. The repetition of a demand.
REMANDEDremanded v. Simple past tense and past participle of remand.
REMAND v. to send back.
REMENDEDremended v. Simple past tense and past participle of remend.
REMEND v. to mend again.
REMINDEDreminded v. Simple past tense and past participle of remind.
REMIND v. to cause to remember.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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