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There are 11 eight-letter words containing 2D, I, O, P and S

DIOPSIDEdiopside n. (Mineralogy) A monoclinic pyroxene mineral, a magnesium calcium silicate with the chemical formula CaMgSi…
DIOPSIDE n. a mineral, a crystallized variety of pyroxene, of a clear, grayish green color.
DIPLOIDSdiploids n. Plural of diploid.
DIPLOID n. an animal with two homologous sets of chromosomes.
DIPODIESdipodies n. Plural of dipody.
DIPODY n. a verse of two metrical feet, also DIMETER.
DISPLODEdisplode v. (Intransitive) To burst with a loud report; to explode.
displode v. (Transitive) To discharge; to explode.
DISPLODE v. (Milton) to discharge; to explode.
DISPONEDdisponed v. Simple past tense and past participle of dispone.
DISPONE v. to make a legal transfer.
DISPOSEDdisposed v. Simple past tense and past participle of dispose.
disposed adj. Inclined; minded.
disposed adj. (In combination) Having a certain disposition.
DROPSIEDdropsied adj. Diseased with dropsy (edema).
DROPSIED adj. (Shakespeare) diseased with dropsy.
LOPSIDEDlopsided adj. Not even or balanced; not the same on one side as on the other.
lopsided adj. (Figurative) biased; not balanced between points of view.
lop-sided adj. Alternative form of lopsided.
PIDDOCKSpiddocks n. Plural of piddock.
PIDDOCK n. a rough-shelled, boring, marine bivalve.
PODDIESTpoddiest adj. Superlative form of poddy: most poddy.
PODDY adj. corpulent.
SPODDIERSPODDY adj. boring, studious.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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