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There are 12 words containing 2D, M, O and 2T

AUTODIDACTICISMautodidacticism n. Self-education; self-directed learning.
AUTODIDACTICISM n. the state of being autodidactic.
COADMITTEDcoadmitted v. Simple past tense and past participle of coadmit.
COADMIT v. to admit several things equally.
DECOMMITTEDdecommitted v. Simple past tense and past participle of decommit.
DECOMMIT v. to withdraw from a commitment.
DECONTAMINATEDdecontaminated v. Simple past tense and past participle of decontaminate.
DECONTAMINATE v. to rid of contamination.
DEMONSTRATEDdemonstrated v. Simple past tense and past participle of demonstrate.
DEMONSTRATE v. to show clearly.
DEMOTIVATEDdemotivated v. Simple past tense and past participle of demotivate.
demotivated adj. Deprived or showing a decrease in motivation.
DEMOTIVATE v. to remove motivation from.
DOMESTICATEDdomesticated v. Simple past tense and past participle of domesticate.
domesticated adj. (Of an animal or a plant, especially a pet) selectively bred to live with or around humans.
DOMESTICATE v. to bring into domestic use.
MASTOIDITIDESmastoiditides n. Plural of mastoiditis.
MASTOIDITIS n. inflammation of mastoid cells.
MUTTONHEADEDmuttonheaded adj. (Britain, slang) Being a muttonhead; stupid or foolish.
MUTTONHEADED adj. stupid.
OVERMULTITUDEDOVERMULTITUDE v. (Milton) to outnumber.
UNDEMONSTRATEDundemonstrated adj. Not demonstrated.
UNDEMONSTRATED adj. not demonstrated.
UNDOMESTICATEDundomesticated adj. Not domesticated.
UNDOMESTICATE v. to make not domesticated.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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