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There are 13 words containing D, 2E, 2F and M

BEMUFFLEDbemuffled adj. Wrapped with, or as if with, a muffler.
BEMUFFLE v. to wrap or muffle.
MUFFLEREDmufflered adj. Wearing a muffler.
MUFFLERED adj. wearing a muffler.
REAFFIRMEDreaffirmed v. Simple past tense and past participle of reaffirm.
REAFFIRM v. to affirm again.
EFFEMINATEDeffeminated v. Simple past tense and past participle of effeminate.
EFFEMINATE v. (archaic) to render effeminate.
EFFEMINISEDeffeminised v. Simple past tense and past participle of effeminise.
EFFEMINISE v. (archaic) to make effeminate, also EFFEMINIZE.
EFFEMINIZEDeffeminized v. Simple past tense and past participle of effeminize.
EFFEMINIZE v. (archaic) to make effeminate.
FLAMEPROOFEDflameproofed v. Simple past tense and past participle of flameproof.
FLAMEPROOF v. to make resistant to damage or burning on contact with flame.
DIFFRACTOMETERdiffractometer n. A device that uses diffraction (especially X-ray diffraction) to investigate the structure of matter.
DIFFRACTOMETER n. an instrument for determining structure of crystal through light diffraction.
INDIFFERENTISMindifferentism n. (Religion) The doctrine that all religions are equally valid.
indifferentism n. (More broadly) Relativism, agnosticism; apathy, indifference.
indifferentism n. (Countable) An expression of such a doctrine or view.
DEXFENFLURAMINEdexfenfluramine n. A serotonergic anorectic drug used for weight loss in the 1990s, later withdrawn because of cardiovascular…
DIFFRACTOMETERSdiffractometers n. Plural of diffractometer.
DIFFRACTOMETER n. an instrument for determining structure of crystal through light diffraction.
DISAFFORESTMENTdisafforestment n. Disafforestation.
DISAFFORESTMENT n. the act of disafforesting.
INDIFFERENTISMSindifferentisms n. Plural of indifferentism.
INDIFFERENTISM n. the belief that all religions are equally valid.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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