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There are 16 words containing 2D, 4E and F

BEDEAFENED	• bedeafened v. Simple past tense and past participle of bedeafen. • BEDEAFEN v. to make deaf.
DEDIFFERENTIATE	• dedifferentiate v. To lose or reverse differentiation. • DEDIFFERENTIATE v. to effect dedifferentiation, a change by which specialized tissue with several cell types reverts to a generalized and simpler form.
DEFENESTRATED	• defenestrated v. Simple past tense and past participle of defenestrate. • DEFENESTRATE v. to throw out of a window.
DEFORMEDNESSES	• DEFORMEDNESS n. the state of being deformed.
ENFREEDOMED	• enfreedomed v. Simple past tense and past participle of enfreedom. • ENFREEDOM v. (Shakespeare) to set free, also ENFREE.
FATHEADEDNESSES	• FATHEADEDNESS n. FATHEADED, stupid.
FEATHERBEDDED	• featherbedded v. Simple past tense and past participle of featherbed. • feather-bedded v. Simple past tense and past participle of feather-bed. • FEATHERBED v. to pamper; to protect (an industry, workers, etc.) by such practices as overmanning in order to save jobs.
FEATHEREDGED	• featheredged v. Simple past tense and past participle of featheredge. • feather␣edged v. Simple past tense and past participle of feather edge. • FEATHEREDGE v. to provide with feathered edge.
FEATHERHEADED	• featherheaded adj. Alternative form of feather-headed. • feather-headed adj. (Colloquial) giddy; frivolous; foolish. • FEATHERHEADED adj. foolish, empty-headed.
FEEBLEMINDED	• feebleminded adj. Alternative spelling of feeble-minded. • feeble-minded adj. Weak in intellectual power; lacking firmness or constancy; lacking intelligence. • FEEBLEMINDED adj. mentally deficient.
FEEBLEMINDEDLY	• feeblemindedly adv. Alternative form of feeble-mindedly. • feeble-mindedly adv. In a feeble-minded manner; as if feeble-minded. • FEEBLEMINDED adv. mentally deficient.
FIDDLEDEDEE	• fiddlededee interj. Alternative spelling of fiddledeedee. • FIDDLEDEDEE interj. an exclamation of impatience, disbelief, or disagreement, also FIDDLEDEEDEE.
FIDDLEDEEDEE	• fiddledeedee interj. (Colloquial, dated) nonsense; rubbish. • FIDDLEDEEDEE interj. an exclamation of impatience, disbelief, or disagreement, also FIDDLEDEDEE.
FREEHANDEDNESS	• freehandedness n. The quality or state of being freehanded. • free-handedness n. Alternative form of freehandedness. • FREEHANDED n. openhanded, liberal.
REDEFEATED	• redefeated v. Simple past tense and past participle of redefeat. • REDEFEAT v. to defeat again.
REDEFECTED	• redefected v. Simple past tense and past participle of redefect. • re-defected v. Simple past tense and past participle of re-defect. • REDEFECT v. to defect again.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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English Wiktionary: 245 words
Scrabble in French: 29 words
Scrabble in Spanish: 33 words
Scrabble in Italian: 71 words
Scrabble in German: no word
Scrabble in Romanian: 1 word

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