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There are 17 words containing 2D, E, F, 2S and U

DEFOCUSSEDdefocussed v. Simple past tense and past participle of defocus.
DEFOCUS v. to cause to go out of focus.
DISULFIDESdisulfides n. Plural of disulfide.
DISULFIDE n. a sulphide containing two atoms of sulphur to the molecule, also DISULFID, DISULPHIDE, DISULPHURET.
FIDDIOUSESFIDDIOUS v. (Shakespeare) to treat as leniently as Coriolanus treated Aufidius.
DEFEUDALISESdefeudalises v. Third-person singular simple present indicative form of defeudalise.
DEFEUDALISE v. to deprive of feudal character, also DEFEUDALIZE.
DESULFURISEDdesulfurised v. Simple past tense and past participle of desulfurise.
DESULFURISE v. to remove the sulfur from a compound, also DESULFURIZE, DESULPHURISE, DESULPHURIZE.
DIFFUSEDNESSdiffusedness n. The state or quality of being diffused.
DIFFUSEDNESS n. the state of being diffused.
DISFURNISHEDdisfurnished v. Simple past tense and past participle of disfurnish.
disfurnished adj. Deprived of furniture, accoutrements or belongings; stripped, destitute.
DISFURNISH v. to strip, render destitute.
DREADFULNESSdreadfulness n. The characteristic of being dreadful.
DREADFULNESS n. the state of being dreadful.
UNFOUNDEDNESSunfoundedness n. The state or condition of being unfounded.
UNFOUNDEDNESS n. the state of being unfounded.
CONFOUNDEDNESSconfoundedness n. The state or quality of being confounded.
CONFOUNDEDNESS n. the state of being confounded.
DIFFUSEDNESSESDIFFUSEDNESS n. the state of being diffused.
DISDAINFULNESSdisdainfulness n. The state or quality of being disdainful.
DISDAINFUL n. full of or expressing disdain, also SDEIGNFULL.
DREADFULNESSESdreadfulnesses n. Plural of dreadfulness.
DREADFULNESS n. the state of being dreadful.
SCHADENFREUDESschadenfreudes n. Plural of schadenfreude.
SCHADENFREUDE n. (German) enjoyment gained from others' troubles.
SULFADIMIDINESSULFADIMIDINE n. a sulpha drug used in human and veterinary medicine.
UNFRIENDEDNESSunfriendedness n. (Archaic) friendlessness.
UNFRIENDEDNESS n. the state of being unfriended.
UNFOUNDEDNESSESUNFOUNDEDNESS n. the state of being unfounded.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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