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There are 5 words containing 2D, 2F, 2I and R

DEDIFFERENTIATE	• dedifferentiate v. To lose or reverse differentiation. • DEDIFFERENTIATE v. to effect dedifferentiation, a change by which specialized tissue with several cell types reverts to a generalized and simpler form.
DIFFERENCIED	• DIFFERENCY v. to make or perceive a difference in, also DIFFERENCE.
DIFFERENTIATED	• differentiated v. Simple past tense and past participle of differentiate. • differentiated adj. (Biology, of a cell or tissue) That has taken on a specialized form and function. • DIFFERENTIATE v. to obtain the mathematical derivative of.
DISAFFIRMED	• disaffirmed v. Simple past tense and past participle of disaffirm. • DISAFFIRM v. to assert the contrary of; to contradict.
INTERDIFFUSED	• interdiffused v. Simple past tense and past participle of interdiffuse. • interdiffused adj. Mutually diffused. • INTERDIFFUSE v. to diffuse between.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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English Wiktionary: 87 words
Scrabble in French: 77 words
Scrabble in Spanish: no word
Scrabble in Italian: 53 words
Scrabble in German: no word
Scrabble in Romanian: no word

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