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There are 16 words containing D, 2E, 2R, S and X

DEXTRORSEdextrorse adj. Turning from the left to the right, in the ascending line, as in the spiral inclination of the stem…
DEXTRORSE adj. rising spirally and turning to the left, also DEXTRORSAL.
DEXTRORSELYdextrorsely adv. In a dextrorse manner.
DEXTRORSE adv. rising spirally and turning to the left, also DEXTRORSAL.
DIRECTRIXESdirectrixes n. Plural of directrix.
DIRECTRIX n. a female director, also DIRECTRESS, DIRECTRICE.
EXTERIORISEDexteriorised v. Simple past tense and past participle of exteriorise.
EXTERIORISE v. to make exterior, also EXTERIORIZE.
EXTRAORDINARIESextraordinaries n. Plural of extraordinary.
extra-ordinaries n. Plural of extra-ordinary.
EXTRAORDINARY n. something out of the ordinary.
EXTRUDERSextruders n. Plural of extruder.
EXTRUDER n. something or someone that extrudes.
FERREDOXINSferredoxins n. Plural of ferredoxin.
FERREDOXIN n. an iron-containing plant protein.
HYDROPEROXIDEShydroperoxides n. Plural of hydroperoxide.
HYDROPEROXIDE n. a compound containing an O2H group.
MODERATRIXESmoderatrixes n. Plural of moderatrix.
MODERATRIX n. (obsolete) a female moderator.
OVEREXERCISEDoverexercised v. Simple past tense and past participle of overexercise.
OVEREXERCISE v. to exercise to excess.
REEXPRESSEDreexpressed v. Simple past tense and past participle of reexpress.
reëxpressed v. Simple past tense and past participle of reëxpress.
re-expressed v. Simple past tense and past participle of re-express.
UNDEREXPOSUREunderexposure n. The condition of being underexposed.
underexposure n. An insufficient, or less than usual, exposure.
UNDEREXPOSURE n. insufficient exposure.
UNDEREXPOSURESunderexposures n. Plural of underexposure.
UNDEREXPOSURE n. insufficient exposure.
XERODERMASxerodermas n. Plural of xeroderma.
XERODERMA n. morbid dryness of skin, ichthyosis, also XERODERMIA.
XERODERMATOUSxerodermatous adj. Exhibiting or relating to xeroderma.
XERODERMATOUS adj. suffering from xeroderma, morbid dryness of skin.
XERODERMIASXERODERMIA n. morbid dryness of skin, ichthyosis, also XERODERMA.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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