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There are 17 five-letter words containing E, L, P and R

LEPERleper n. A person who has leprosy, a person suffering from Hansen’s disease.
leper n. (Figurative) Synonym of outcast: A person who is shunned, a pariah.
leper v. (Now rare) To afflict with leprosy.
LEPRAlepra n. (Medicine, archaic) Synonym of leprosy.
lepra n. (Medicine, obsolete) Synonym of psoriasis.
lepra n. (Botany, rare, obsolete) Any layer of algae, lichens, or other substance producing a leprosylike appearance…
LERPSlerps n. Plural of lerp.
LERP n. (Native Australian) in Australia, a scalelike, waxy, protective, edible secretion produced on the leaves of certain plant louse larvae.
LOPERloper n. One who or that which lopes; a runner; a leaper.
loper n. (Ropemaking) A swivel placed at one end of the ropewalk, with the whirl being at the opposite end.
loper n. (Southwestern US dialects) A wolf, especially a grey or timber wolf.
PALERpaler adj. Comparative form of pale: more pale.
PALE adj. lacking colour.
PARLEparle n. (Obsolete) Parley; talk.
parle n. (Obsolete) A nasty encounter.
parle v. (Obsolete, intransitive) To talk; to converse; to parley.
PEARLpearl n. A shelly concretion, usually rounded, and having a brilliant luster, with varying tints, found in the…
pearl n. (Figuratively) Something precious.
pearl n. A capsule of gelatin or similar substance containing liquid for e.g. medicinal application.
PERILperil n. A situation of serious and immediate danger.
peril n. Something that causes, contains, or presents danger.
peril n. (Insurance) An event which causes a loss, or the risk of a specific such event.
PILERpiler n. One who piles something.
PILER n. one who places things in a pile.
PLIERplier n. One who plies.
plier n. Attributive form of pliers.
PLIER n. one who plies, also PLYER.
PLYERplyer n. A kind of balance used in raising and letting down a drawbridge. It consists of timbers joined in the…
plyer n. Alternative spelling of plier.
PLYER n. one who plies, also PLIER.
POLERpoler n. One who propels a boat using a pole.
poler n. A horse harnessed alongside the shaft or pole of a vehicle.
poler n. (Obsolete) An extortioner.
PROLEprole n. (Informal) A member of the proletariat; a proletarian.
prole n. (Informal) A pleb (ordinary person).
PROLE v. to prowl, also PROLL, PROUL.
PULERpuler n. One who pules; one who whines or complains; a weak person.
PULER n. one who pules.
REPELrepel v. (Transitive, now rare) To turn (someone) away from a privilege, right, job, etc.
repel v. (Transitive) To reject, put off (A request, demand etc.).
repel v. (Transitive) To ward off (A malignant influence, attack etc.).
REPLArepla n. Plural of replum.
REPLUM n. (Latin) a partition in fruit.
REPLYreply v. (Transitive, intransitive) To give a written or spoken response, especially to a question, request…
reply v. (Intransitive) To act or gesture in response.
reply v. (Intransitive) To repeat something back; to echo.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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