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There are 19 fifteen-letter words containing 2E, H, S and X

ARCHAEOPTERYXESarchaeopteryxes n. Plural of archaeopteryx.
ARCHAEOPTERYX n. a Jurassic fossil bird of the Archaeopteryx genus, with a long bony tail, sharp-toothed jaws, and wings bearing three clawed digits.
CEPHALOTHORAXEScephalothoraxes n. Plural of cephalothorax.
CEPHALOTHORAX n. the body, or head with thorax, of spiders, crustaceans, etc.
CHEMOTAXONOMIESchemotaxonomies n. Plural of chemotaxonomy.
CHEMOTAXONOMY n. the classification of plants and animals based on similarities and differences in biochemical composition.
DEXAMPHETAMINESDEXAMPHETAMINE n. the dextrorotatory isomer of amphetamine, used as a stimulant.
EXHAUSTLESSNESSexhaustlessness n. (Dated) inexhaustibility; infinite supply.
EXHAUSTLESS n. inexhaustible.
EXOTHERMICITIESexothermicities n. Plural of exothermicity.
EXOTHERMICITY n. the state of being exothermic.
EXTINGUISHMENTSextinguishments n. Plural of extinguishment.
EXTINGUISHMENT n. the act of extinguishing.
HETEROFLEXIBLESheteroflexibles n. Plural of heteroflexible.
HETEROFLEXIBLE n. one of flexible sexual orientation.
HETEROSEXUALITYheterosexuality n. The state of being sexually and romantically attracted primarily or exclusively to persons of the opposite sex.
heterosexuality n. Sexual activity with a person of the opposite sex.
HETEROSEXUALITY n. the state of being heterosexual.
HEXOSAMINIDASEShexosaminidases n. Plural of hexosaminidase.
HEXOSAMINIDASE n. either of two hydrolytic enzymes that catalyze the splitting off of a hexose from a ganglioside and are deficient in some metabolic diseases.
HEXYLRESORCINOLhexylresorcinol n. (Organic chemistry) A hexyl derivative of resorcinol that has anaesthetic, antiseptic and antihelmintic properties.
HEXYLRESORCINOL n. a crystalline phenol used as an antiseptic and anthelmintic.
HIERACOSPHINXEShieracosphinxes n. Plural of hieracosphinx.
HIERACOSPHINX n. in ancient Egyptian art, a hawk-headed sphinx.
HOMOSEXUALITIEShomosexualities n. Plural of homosexuality.
HOMOSEXUALITY n. the state of being homosexual.
HYPEREXCRETIONSHYPEREXCRETION n. excessive excretion.
HYPEREXTENSIONShyperextensions n. Plural of hyperextension.
HYPEREXTENSION n. the extension of a joint beyond its normal range.
METHOXYBENZENESmethoxybenzenes n. Plural of methoxybenzene.
METHOXYBENZENE n. another name for anisole, a colourless liquid ether.
METHOXYFLURANESmethoxyfluranes n. Plural of methoxyflurane.
METHOXYFLURANE n. a potent general anaesthetic administered as a vapor.
METHYLXANTHINESmethylxanthines n. Plural of methylxanthine.
METHYLXANTHINE n. a methylated xanthine derivative, such as caffeine, theobromine, or theophylline.
NONHETEROSEXUALnonheterosexual adj. Alternative form of non-heterosexual.
nonheterosexual n. Alternative form of non-heterosexual.
non-heterosexual adj. Not heterosexual.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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