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There are 8 fifteen-letter words containing E, H, 2S and X

EXHAUSTLESSNESSexhaustlessness n. (Dated) inexhaustibility; infinite supply.
EXHAUSTLESS n. inexhaustible.
EXTINGUISHMENTSextinguishments n. Plural of extinguishment.
EXTINGUISHMENT n. the act of extinguishing.
HEXOSAMINIDASEShexosaminidases n. Plural of hexosaminidase.
HEXOSAMINIDASE n. either of two hydrolytic enzymes that catalyze the splitting off of a hexose from a ganglioside and are deficient in some metabolic diseases.
HIERACOSPHINXEShieracosphinxes n. Plural of hieracosphinx.
HIERACOSPHINX n. in ancient Egyptian art, a hawk-headed sphinx.
HOMOSEXUALITIEShomosexualities n. Plural of homosexuality.
HOMOSEXUALITY n. the state of being homosexual.
HYPEREXTENSIONShyperextensions n. Plural of hyperextension.
HYPEREXTENSION n. the extension of a joint beyond its normal range.
LEXICOGRAPHISTSlexicographists n. Plural of lexicographist.
LEXICOGRAPHIST n. one who makes dictionaries.
PSYCHOSEXUALITYpsychosexuality n. The psychological aspects of sexuality.
PSYCHOSEXUALITY n. the psychic factors of sex.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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