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There are 4 five-letter words containing E, M, R, S and U

MURESmures n. Plural of mure.
Mureș prop.n. A river which runs through Romania, starting in the eastern Carpathians and joining the Tisza in Hungary…
Mureș prop.n. A county of Transylvania, Romania, with the administrative centre in Târgu Mureș.
MUSERmuser n. One who muses.
muser n. (Historical) A user of the social media service Musical.ly.
Muser prop.n. A surname.
RUMESRUME n. (Shakespeare) a watery discharge from the nose or eyes, also RHEUM.
SERUMserum n. The clear yellowish liquid obtained upon separating whole blood into its solid and liquid components…
serum n. Blood serum from the tissues of immunized animals, containing antibodies and used to transfer immunity…
serum n. A watery liquid from animal tissue, especially one that moistens the surface of serous membranes or…

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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