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There are 3 five-letter words containing E, P, S, T and U

SETUPsetup n. Equipment designed for a particular purpose; an apparatus.
setup n. The fashion in which something is organized or arranged.
setup n. A situation orchestrated to frame someone; a covert effort to place the blame on somebody.
STUPEstupe n. (Slang) A stupid person or (rarely) thing.
stupe n. A hot, wet medicated cloth or sponge applied externally.
stupe v. To foment with such a cloth or sponge.
UPSETupset adj. (Of a person) Angry, distressed, or unhappy.
upset adj. (Of a stomach or gastrointestinal tract, referred to as stomach) Feeling unwell, nauseated, or ready to vomit.
upset n. (Uncountable) Disturbance or disruption.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org.

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