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There are 8 six-letter words containing 2E, I, M and P

EMPIREempire n. A political unit, typically having an extensive territory or comprising a number of territories or nations…
empire n. A political unit ruled by an emperor or empress.
empire n. The group of states or other territories that owe allegiance to an imperial power (foreign to them)…
EPIMERepimer n. (Chemistry) Any diastereoisomer that has the opposite configuration at only one of the stereogenic centres.
EPIMER n. a type of sugar compound.
HEMPIEhempie n. (Obsolete, Scotland and Northern England) A criminal; someone who deserves to be, or is likely to be, hanged.
hempie n. (Obsolete, Scotland and Northern England) A rogue.
hempie n. (Obsolete, Scotland and Northern England) A wild, romping girl.
IMPEDEimpede v. (Transitive) To get in the way of; to hinder.
IMPEDE v. to retard by obstructing.
IMPHEEimphee n. (Botany) African sugar cane (Sorghum bicolor, syn. Holcus saccharatus and Andropogon saccharatus).
IMPHEE n. (Zulu) any of several southern African varieties of sorghum.
PERMIEpermie n. (UK, informal) A permanent employee.
PERMIE n. a permanent worker, as opposed to a temp.
PIEMENpiemen n. Plural of pieman.
PIEMAN n. someone who sells pies.
PREMIEpremie n. Alternative spelling of preemie.
premie n. A follower of the controversial spiritual leader Prem Rawat (born 1957).
PREMIE n. (US slang) a premature baby, also PREEMIE, PREM, PREMY.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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