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There are 7 twelve-letter words containing E, M, S and 3U

EQUINUMEROUSequinumerous adj. (Mathematics) Having equal cardinality.
EQUINUMEROUS adj. having the same number of members.
MUSCULATURESmusculatures n. Plural of musculature.
MUSCULATURE n. the muscles of all or a part of the animal body.
NEUROHUMOURSneurohumours n. Plural of neurohumour.
NEUROHUMOUR n. a neurohormone, esp. a neurotransmitter, also NEUROHUMOR.
PLUMULACEOUSplumulaceous adj. (Zoology, ornithology) Downy; bearing down.
PLUMULACEOUS adj. of or like plumulae, little feathers.
PRESUMPTUOUSpresumptuous adj. Going beyond what is right, proper, or appropriate because of an excess of self-confidence or arrogance.
PRESUMPTUOUS adj. overstepping due bounds (as of propriety or courtesy).
SUBOPERCULUMsuboperculum n. (Anatomy) The lower opercular bone in fishes.
SUBOPERCULUM n. in fishes, a bone below and partly behind the gill cover.
SUPERNACULUMsupernaculum adv. (Obsolete) According to the rules of an old drinking game in which the drinker upturned the empty cup…
supernaculum adv. To the last drop, to the bottom.
supernaculum n. (Obsolete) Excellent wine that one would wish to drink to the last drop.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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