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There are 6 six-letter words containing E, I, N, R, S and U

ERINUSERINUS n. any rock plant of the genus Erinus.
INSUREinsure v. (Transitive) To provide for compensation if some specified risk occurs. Often agreed by policy (contract)…
insure v. (Intransitive) To deal in such contracts; subscribe to a policy of insurance.
insure v. (Chiefly US, transitive, dated) Alternative spelling of ensure; to make sure or certain of; guarantee.
INURESinures v. Third-person singular simple present indicative form of inure.
INURE v. to accustom oneself to accept unpleasant things.
RUSINErusine adj. (Zoology) Of, like, or relating to, a deer of the genus Rusa.
rusine adj. (Zoology, of an antler) Having the brow tine simple, and the beam forked at the tip.
RUSINE adj. pertaining to a deer of the genus Rusa, which includes the sambur deer of India.
URINESurines n. Plural of urine.
URINE v. to discharge a liquid containing body wastes.
URSINEursine adj. Of, pertaining to, or characteristic of bears.
ursine adj. Of, pertaining to, or characteristic of the bear subfamily Ursinae.
ursine adj. (Entomology, of caterpillars) Covered in stiff bristles.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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