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There are 3 seven-letter words containing 2I, 2O and P

OPINIONopinion n. A belief, judgment or perspective that a person has formed, either through objective or subjective reasoning…
opinion n. The judgment or sentiment which the mind forms of persons or things; estimation.
opinion n. (Obsolete) Favorable estimation; hence, consideration; reputation; fame; public sentiment or esteem.
OPIOIDSopioids n. Plural of opioid.
OPIOID n. a peptide that acts like opium.
PIOPIOSpiopios n. Plural of piopio.
PIOPIO n. (Maori) a New Zealand thrush, thought to be extinct.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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