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There are 8 eight-letter words containing 2I, P, S and X

APOMIXISapomixis n. (Botany) Plant reproduction without fertilization.
apomixis n. (Botany) Plant reproduction without fertilization, meiosis, or the production of gametes.
apomixis n. (Zoology) Animal reproduction in which the egg cell does not undergo meiosis or fertilization.
EPITAXISEPITAXIS n. the part of a play in which the main action develops, also EPITASIS.
EXPIRIESexpiries n. Plural of expiry.
EXPIRY n. expiration; death.
PANMIXISpanmixis n. (Ecology) Panmixia.
PANMIXIS n. (Greek) random mating within a breeding population, also PANMIXIA.
PIXIEISHpixieish adj. Alternative spelling of pixyish.
PIXIEISH adj. like a pixie.
PIXINESSpixiness n. Quality of being pixyish.
PIXINESS n. the state of being playfully mischievous.
SPINIFEXspinifex n. An Australian coastal grass, in genus Spinifex.
spinifex n. (Australia) A coastal grass, either in genera Triodia or Spinifex.
SPINIFEX n. (Latin) a sharp-pointed Australian grass.
XIPHOIDSxiphoids n. Plural of xiphoid.
XIPHOID n. the xiphoid process or xiphisternum.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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