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There are 11 ten-letter words containing 3I, 2R and S

CRITICISERcriticiser n. Non-Oxford British spelling standard spelling of criticizer.
CRITICISER n. one who criticises, also CRITICIZER.
INSPIRITERINSPIRITER n. one who inspirits.
KIRBIGRIPSkirbigrips n. Plural of kirbigrip.
KIRBIGRIP n. (tradename) a kind of hairgrip.
LIBRAIRIESLIBRAIRIE n. (French) a bookshop.
NITRIFIERSnitrifiers n. Plural of nitrifier.
NITRIFIER n. an agent employed in nitrification.
PRIORITIESpriorities n. Plural of priority.
priorities interj. (Informal) An expression, chiefly unfriendly, remarking disagreement with someone else’s order of priorities;…
PRIORITY n. precedence established by importance.
PRIORITISEprioritise v. (British spelling) Alternative form of prioritize.
PRIORITISE v. to assign a priority to, also PRIORITIZE.
REINSPIRITreinspirit v. (Transitive) To give fresh spirit to.
REINSPIRIT v. to give fresh spirit to.
RIBAVIRINSribavirins n. Plural of ribavirin.
RIBAVIRIN n. a synthetic guanosine analogue, which interferes with the synthesis of viral nucleic acids and is used to treat viral infections.
RIGORISTICrigoristic adj. Exhibiting rigorism; strict.
RIGORISTIC adj. relating to rigorism.
TRINITRINSTRINITRIN n. glyceryl trinitrate, used to treat angina pectoris.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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