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There are 5 ten-letter words containing 2I, P, R and 2U

EPINEURIUMepineurium n. (Anatomy) The connective tissue framework and sheath of a nerve which bind together the nerve bundles…
EPINEURIUM n. the connective tissue framework and sheath of a nerve.
PURLICUINGPURLICUE v. to summarise in conclusion, also PIRLICUE.
SPIRITUOUSspirituous adj. Of, pertaining to, containing, or made using alcohol.
spirituous adj. (Of an alcoholic drink) Distilled.
SPIRITUOUS adj. alcoholic.
SUSPIRIOUSsuspirious adj. Suspiring; sighing.
SUSPIRIOUS adj. breathing labouredly; sighing.
UNPURIFIEDunpurified adj. Not purified; impure.
UNPURIFIED adj. not purified.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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