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There are 16 eight-letter words containing 2I, M, N, S and U

IMMUNISEimmunise v. (British spelling) Alternative spelling of immunize.
IMMUNISE v. to render immune from infection, also IMMUNIZE.
INDUSIUMindusium n. (Botany) A protecting membrane, especially that covering the developing spores of a fern.
INDUSIUM n. an enclosing membrane.
INFIMUMSinfimums n. Plural of infimum.
INFIMUM n. (Latin) a mathematical term for the greatest lower bound.
LUMINISMluminism n. (Art) An American artistic style of the 19th century, characterised by effects of light in landscapes.
LUMINISM n. a style of realist landscape painting.
LUMINISTluminist n. (Painting) A painter who works in the style of luminism.
LUMINIST n. a painter who uses the effects of light.
MINIMUMSminimums n. Plural of minimum.
MINIMUM n. (Latin) the least possible amount.
MISCUINGmiscuing v. Present participle of miscue.
miscuing n. An instance of something being miscued; a miscue.
MISCUE v. to make a faulty stroke in billiards.
MISUNIONmisunion n. A bad or wrong union or alliance.
MISUNION n. a bad union.
MISUSINGmisusing v. Present participle of misuse.
MISUSE v. to use incorrectly.
MUISTINGMUIST v. to powder, also MOUST.
MUNIFIESmunifies v. Third-person singular simple present indicative form of munify.
MUNIFY v. to fortify, also MUNITE.
MUSICIANmusician n. A composer, conductor, or a performer of music; more specifically, it’s a person who sings and/or plays…
MUSICIAN n. one who performs or composes music.
MUTINIESmutinies n. Plural of mutiny.
mutinies v. Third-person singular simple present indicative form of mutiny.
MUTINY v. to revolt against constituted authority, also MUTINE, MUTINEER.
NIOBIUMSniobiums n. Plural of niobium.
NIOBIUM n. a metallic element, formerly called columbium.
UNDINISMundinism n. (Psychology) Sexual arousal from urine or urination.
UNDINISM n. a preoccupation with water.
UNIONISMunionism n. The support of advocacy of a union, especially of a trade union.
unionism n. (Often capitalised) Support for the North (the Union) during the American Civil War.
unionism n. (Often capitalised) Support for the continuance of the United Kingdom (especially with respect to Northern Ireland).

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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