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There are 18 seven-letter words containing M, P, 2S and U

EMPUSASempusas n. Plural of empusa.
EMPUSA n. (Greek) a phantom or specter sent by Hecate, also EMPUSE.
EMPUSESempuses n. Plural of empuse.
EMPUSE n. (Greek) a phantom or spectre sent by Hecate, also EMPUSA.
GYPSUMSgypsums n. Plural of gypsum.
GYPSUM n. hydrated calcium sulphate, a soft mineral used for making plaster of Paris and as a fertilizer.
MASHUPSmashups n. Plural of mashup.
mash-ups n. Plural of mash-up.
MASHUP n. a piece of live or recorded music in which a producer blends together two or more tracks, often from contrasting genres.
MOPUSESmopuses n. Plural of mopus.
MOPUS n. (slang) a small coin, also MAWPUS.
OPOSSUMopossum n. Any American marsupial of the family Didelphidae. The common species of the United States is Didelphis virginiana.
OPOSSUM n. (Native American) any of various small or medium-sized marsupial mammals, mostly arboreal.
PENSUMSpensums n. Plural of pensum.
PENSUM n. (Latin) a task; a school imposition.
POSSUMSpossums n. Plural of possum.
POSSUM v. to feign ignorance (i.e. to play possum).
PURISMSpurisms n. Plural of purism.
PURISM n. strict adherence to traditional correctness.
SCRUMPSscrumps v. Third-person singular simple present indicative form of scrump.
SCRUMP v. to gather windfalls illegally.
SEPIUMSSEPIUM n. cuttlebone, also SEPIOST, SEPIOSTAIRE.
SEPTUMSseptums n. Plural of septum.
SEPTUM n. (Latin) a dividing membrane or partition.
SHLUMPSshlumps n. Plural of shlump.
SHLUMP v. (Yiddish) to dress sloppily, also SCHLUMP.
SKRUMPSSKRUMP v. (colloquial) to steal fruit (esp. apples) from trees, also SCRUMP.
SMASHUPsmashup n. (Informal) An abrupt, damaging breakdown or failure.
smashup n. (Informal) A violent collision involving one or more vehicles.
smashup n. An instance or the result of smashing; that which has been smashed into pieces.
SPUMOUSspumous adj. Frothy or foamy; spumy.
SPUMOUS adj. spumy, full of spume.
SPUTUMSsputums n. Plural of sputum.
SPUTUM n. (Latin) thick mucus coughed up from the respiratory tract esp in certain diseases of the lungs, chest, or throat.
SUMPITSsumpits n. Plural of sumpit.
SUMPIT n. (Malay) a Malay blowpipe made from a hollow cane, also SUMPITAN.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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