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There are 11 twelve-letter words containing 2M, 2O, P and U

AMPHISTOMOUSamphistomous adj. (Zoology) Having a sucker at each extremity.
AMPHISTOMOUS adj. having a sucker at either end, as some worms.
AUTOMORPHISMautomorphism n. (Algebra) An isomorphism of a mathematical object or system of objects onto itself.
automorphism n. The ascription to others of one’s own characteristics.
AUTOMORPHISM n. ascription to others of one's own characteristics.
COMPUTERDOMSCOMPUTERDOM n. the world of computers.
HOMOMORPHOUShomomorphous adj. Characterized by homomorphism.
HOMOMORPHOUS adj. alike in form, esp. if essentially different otherwise.
LYMPHOMATOUSlymphomatous adj. Relating to lymphoma.
LYMPHOMATOUS adj. of or like a lymphoma.
MESOMORPHOUSmesomorphous adj. Mesomorphic.
MESOMORPHOUS adj. relating to a mesomorph.
METAMORPHOUSmetamorphous adj. Metamorphic.
METAMORPHOUS adj. of or relating to metamorphosis (especially of rocks).
MONOMORPHOUSmonomorphous adj. Monomorphic.
MONOMORPHOUS adj. existing in one form only.
MONOSPERMOUSmonospermous adj. (Botany) Having only one seed.
MONOSPERMOUS adj. producing only one seed, also MONOSPERMAL.
POMPELMOUSESpompelmouses n. Plural of pompelmous.
pompelmouses n. Plural of pompelmouse.
POMPELMOUSE n. (Dutch) the shaddock or grapefruit, also PAMPELMOOSE, PAMPELMOUSE, POMELO, POMPELMOOSE, POMPELMOUS, POMPELO, PUMELO, PUMMELO.
SPERMOGONIUMspermogonium n. (Lichenology) A conceptacle of certain lichens, containing spermatia.
SPERMOGONIUM n. a flask-shaped structure in some fungi, also SPERMOGONE.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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