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There are 7 eight-letter words containing 2N, O, T and X

ANATOXINanatoxin n. A bacterial toxin (usually an exotoxin) whose toxicity has been weakened or suppressed.
anatoxin n. A powerful neurotoxin, one of many toxins produced by several species of cyanobacterium.
ANATOXIN n. a potent alkaloid toxin derived from a species of cyanobacteria.
EXPONENTexponent n. One who expounds, represents or advocates.
exponent n. (Mathematics) The number by which a value (called the base) is said to be raised to a power in exponentiation…
exponent n. (Mathematics, obsolete) The degree to which the root of a radicand is found, for example, the 2 in 2]𝑟=𝑏.
NEOTOXINNEOTOXIN n. any harmful substance in the environment causing illness or allergy.
NONTAXESnontaxes n. Plural of nontax.
NONTAX n. a tax of little consequence.
NONTOXICnontoxic adj. Not toxic; not poisonous.
nontoxic n. A substance that is not toxic.
non-toxic adj. Alternative form of nontoxic.
TONNEAUXtonneaux n. Plural of tonneau.
TONNEAU n. (French) the rear extension of the body of a car.
XANTHONExanthone n. (Organic chemistry) An aromatic ketone, 9-oxo-xanthene, that is used as an insecticide.
XANTHONE n. a ketone analogue of xanthene which forms the basis of various natural pigments.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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