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There are 9 twelve-letter words containing 2O, P, U and X

AUTOEXPOSUREautoexposure n. (Photography) automatic selection of exposure settings.
AUTOEXPOSURE n. a system for automatically adjusting the aperture and/or shutter speed of a camera according to the lighting conditions.
AUXOTROPHIESauxotrophies n. Plural of auxotrophy.
AUXOTROPHY n. the state of being auxotrophic, requiring a specific growth substance beyond the minimum required for normal metabolism.
EXPOSTULATORexpostulator n. One who expostulates.
EXPOSTULATOR n. one who expostulates.
GROUNDPROXESGROUNDPROX n. an altitude warning system in aircraft.
OVEREXPOSUREoverexposure n. Excessive exposure.
overexposure n. Of a famous person, excessive publicity, publication or reporting regarding that person.
overexposure n. (Photography) Exposure of film to light during the development process for a longer time than is required…
OXYCEPHALOUSOXYCEPHALOUS adj. having a conical skull, also OXYCEPHALIC.
PNEUMOTHORAXpneumothorax n. (Medicine) Presence of air inside the pleural cavity, usually caused by injury either to the lung or the chest wall.
PNEUMOTHORAX n. accumulation of air or gas in the pleural cavity.
POSTEXPOSUREpostexposure adj. After exposure (To radiation, pathogens, etc.).
POSTEXPOSURE adj. taking place after exposure.
XEROMORPHOUSxeromorphous adj. Xeromorphic.
XEROMORPHOUS adj. of parts of a plant, protected against excessive loss of water by thick cuticles, coatings of hairs and similar structural features, also XEROMORPHIC.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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